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Smoking: A Direct Hit to the Heart Every puff of a cigarette is a direct challenge to your cardiovascular system. Beyond the lungs, the chemicals in tobacco smoke enter your bloodstream How Long Does Nicotine Stay in Your System? Addiction Rehab Exposed to Tobacco Circulating Now from the NLM Historical Collections Heated tobacco and cigarettes cause the same gut and vascular damage, study finds How Smoking and Nicotine Damage Your Body American Heart Association

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